According to Dr. Lyftogt, many chronic pain conditions result from neurogenic inflammation. When a nerve becomes chronically inflamed, it can no longer establish the resting membrane potential of a healthy non-inflamed nerve. This leads to more frequent and intense pain signals relayed to the brain by the inflamed nerve, resulting in perceived chronic pain. Neural prolotherapy targets these inflamed nerves and uses micro-dose subcutaneous injections to restore a normal resting membrane potential and healthy pain response.